CSS Flexbox python is a layout model that provides an efficient way to align, distribute, and space elements inside a container, even when their sizes are dynamic. It works by defining a flex container using display: flex;, which enables its child elements (flex items) to be arranged along a main axis (horizontal or vertical) while allowing flexibility in size and positioning. Key properties include justify-content, which controls alignment along the main axis, align-items for cross-axis alignment, and flex-wrap to determine whether items should wrap onto new lines when they exceed container space. Individual flex items can be adjusted using properties like flex-grow, flex-shrink, and flex-basis to control their size and responsiveness. Unlike traditional layouts like float and inline-block, Flexbox provides a more intuitive way to create responsive and adaptive designs, making it ideal for building modern web interfaces.